- The Office's current Director is William Dean. It has deputy directorates for two areas: (1) Reactor Safety Programs and (2)Engineering and Corporate Support. It has program management, policy development and analysis staff as well as an array of divisions. The Office of Nuclear Reactor Regulation is responsible for ensuring the public health and safety through licensing and inspection activities at commercial nuclear power plants. However, the actual evaluation of license renewal applications, known as LRA's, is conducted by the Division of License Renewal, a subordinated Division of the multifaceted NRR.
- Harold Ray Denton (February 24, 1936 – February 13, 2017) was the Director of the Office of Nuclear Reactor Regulation at the United States Nuclear Regulatory Commission (USNRC) and is best known for his role as President Jimmy Carter's personal adviser for the Three Mile Island (TMI) accident.
After graduating in 1958 with a Bachelor of Science in nuclear engineering from North Carolina State University College of Engineering, Denton first worked at DuPont as an engineer for several years, before being hired by the USNRC. After 10 years, he became the Director of the Office of Nuclear Reactor Regulation, a position he held until his retirement in 1998
As director, he held a a job that allowed him to see a extremely high granular TMI view of the NRC and the nuclear industry. He was another failed bureaucrat who came to the request of another failed president.